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Antioxidant diet preserves endothelium-dependent vasodilatation in resistance arteries of hypercholesterolemic rabbits exposed to environmental tobacco smoke

Journal of Cardiovascular Pharmacology, ISSN: 0160-2446, Vol: 31, Issue: 5, Page: 649-653
1998
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Article Description

Environmental tobacco smoke (ETS) has been shown to Impair endothelium- dependent vasodilation In vitro. This study was performed to investigate the effect of ETS on acetylcholine (ACh)-mediated blood pressure changes in vivo. Seventeen New Zealand White rabbits were fed a cholesterol diet (0.3%) for 13 weeks. Ten animals were exposed to ETS for 6 h/day, and seven animals were not exposed to ETS (non-ETS). Four of the ETS and three of the non-ETS- exposed rabbits received an antioxidant vitamin diet before and during their cholesterol diet for 21 weeks. Six rabbits served as healthy controls. To determine endothelium-dependent and independent blood pressure (BP) responses, BP was measured through a Tygon catheter, inserted into the right carotid artery at baseline and after each of three incremental intravenous doses of norepinephrine (NE; 1, 4, and 20 μg/kg), ACh (3.3, 10, and 30 μg/kg), and nitroglycerin (NTG; 1, 10, and 40 μg/kg). After NE, BP increases were significantly attenuated in the ETS group (p = 0.001) but not in animals receiving the antioxidant supplement. At both the middle and high ACh concentrations, ETS (p = 0.03 and p = 0.01, respectively) and hypercholesterolemia (p = 0.03 and p = 0.06, respectively) attenuated ACh- induced reductions in BP. At the highest ACh concentration, vitamins enhanced the reduction in BP (p = 0.002) and blocked the effect of ETS (p = 0.04). Neither ETS nor vitamins influenced NTG-induced decreases in BP. A combined antioxidant-vitamin diet can preserve endothelium-dependent vasodilatation in the hypercholesterolemic rabbit exposed to ETS.

Bibliographic Details

Severin P. Schwarzacher; Stuart Hutchison; Tony M. Chou; Yi Ping Sun; Bo Qing Zhu; Kanu Chatterjee; Stanton A. Glantz; Prakash C. Deedwania; William W. Parmley; Krishnankutty Sudhir

Ovid Technologies (Wolters Kluwer Health)

Pharmacology, Toxicology and Pharmaceutics; Medicine

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