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Clinical measurement, statistical analysis, and risk-benefit: Controversies from trials of spinal injury

Journal of Trauma - Injury, Infection and Critical Care, ISSN: 1529-8809, Vol: 48, Issue: 3, Page: 558-561
2000
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Article Description

Background: The National Acute Spinal Cord Injury Studies have been a series of trials assessing the role of pharmacologic agents in the prevention of secondary neuronal damage after acute spinal cord injury. Methods: The trials were multicenter randomized, controlled studies. Results: Two trials have demonstrated the efficacy of high-dose methylprednisolone in improving neurologic and functional recovery and have shown a reassuring safety profile. Conclusion: This study responds to a recent commentary on these trials and examines in particular the roles of clinical measurement, statistical analysis, and risk benefit in assembling evidence for or against innovative therapies.

Bibliographic Details

Michael B. Bracken; E. Francois Aldrich; Daniel L. Herr; Patrick W. Hitchon; Theodore R. Holford; Lawrence F. Marshall; Russ P. Nockels; Valentine Pascale; Mary Jo Shepard; Volker K. H. Sonntag; H. Richard Winn; Wise Young

Ovid Technologies (Wolters Kluwer Health)

Medicine

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