The nitric oxide donor sodium nitroprusside is protective in ischemia/reperfusion injury of the pancreas
Transplantation, ISSN: 0041-1337, Vol: 66, Issue: 8, Page: 994-999
1998
- 28Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations28
- Citation Indexes28
- 28
- CrossRef22
- Captures4
- Readers4
Article Description
Background. The role of nitric oxide in the ischemia/reperfusion injury of the pancreas is still unclear. In other organs, protective as well as aggravating effects have been described. We have, therefore, investigated the effect of the nitric oxide donor sodium nitroprusside on pancreatic ischemia/reperfusion injury. Methods. In Landrace pigs, after transsection of the pancreas, complete vascular isolation of the pancreatic tail was performed. The tail was subjected to 3 hr of warm ischemia and thereafter reperfusion (6 hr). The animals were divided into a control group (n=7) and a treatment group (n=7) that received 15 mg of sodium nitroprusside after reperfusion intra-arterially into the splenic artery. Results. The morphological tissue damage and lipase activity in the venous effluent of the pancreas were significantly lower in the treatment group. Partial oxygen tension in the tissue after reperfusion was markedly reduced in the control group, indicating an impairment of microcirculation. In the treatment group, however, partial oxygen tension in the tissue was significantly higher (43 vs. 20 mmHg; P<0.014). Furthermore, total blood flow through the pancreatic tail in the treatment group was found to be significantly higher in the late reperfusion period (14 vs. 9.5 ml/min at 5 hr after reperfusion; P<0.05). Conclusion. There is a marked impairment of pancreatic microcirculation after reperfusion. Sodium nitroprusside counteracts this impairment and has a protective effect on ischemia/reperfusion injury of the pancreas.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032573041&origin=inward; http://dx.doi.org/10.1097/00007890-199810270-00005; http://www.ncbi.nlm.nih.gov/pubmed/9808481; http://journals.lww.com/00007890-199810270-00005; https://dx.doi.org/10.1097/00007890-199810270-00005; https://journals.lww.com/transplantjournal/Fulltext/1998/10270/THE_NITRIC_OXIDE_DONOR_SODIUM_NITROPRUSSIDE_IS.5.aspx
Ovid Technologies (Wolters Kluwer Health)
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