Physiological importance of aquaporins: Lessons from knockout mice
Current Opinion in Nephrology and Hypertension, ISSN: 1062-4821, Vol: 9, Issue: 5, Page: 517-522
2000
- 74Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations74
- Citation Indexes74
- 74
- CrossRef59
- Captures12
- Readers12
- 12
Review Description
The phenotype analysis of transgenic mice deficient in specific aquaporin water channels has provided new insights into the role of aquaporins in organ physiology. AQP1-deficient mice are polyuric and are unable to concentrate their urine in response to water deprivation or vasopressin administration. AQP1 deletion reduces osmotic water permeability in the proximal tubule, thin descending limb of Henle and vasa recta, resulting in defective proximal tubule fluid absorption and medullary countercurrent exchange. Mice lacking AQP3, a basolateral membrane water channel expressed mainly in the cortical collecting duct, are remarkably polyuric but are able to generate a partly concentrated urine after water deprivation. In contrast, mice lacking AQP4, a water channel expressed mainly in the inner medullary collecting duct, manifest only a mild defect in maximum urinary concentrating ability. These data, together with phenotype analyses of the brain, lung, salivary gland, and gastrointestinal organs, support the paradigm that aquaporins can facilitate near-isosmolar transepithelial fluid absorption/secretion as well as rapid vectorial water movement driven by osmotic gradients. The phenotype data obtained from aquaporin knockout mice suggest the utility of aquaporin blockers as novel diuretic agents. (C) 2000 Lippincott Williams and Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033862584&origin=inward; http://dx.doi.org/10.1097/00041552-200009000-00010; http://www.ncbi.nlm.nih.gov/pubmed/10990371; http://journals.lww.com/00041552-200009000-00010; https://dx.doi.org/10.1097/00041552-200009000-00010; https://journals.lww.com/co-nephrolhypertens/Abstract/2000/09000/Physiological_importance_of_aquaporins__lessons.10.aspx
Ovid Technologies (Wolters Kluwer Health)
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