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Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia

Journal of Pediatric Hematology/Oncology, ISSN: 1077-4114, Vol: 25, Issue: 5, Page: 403-404
2003
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Article Description

All-trans-retinoic acid (ATRA) has a dramatic antitumor effect in patients with acute promyelocytic leukemia (APL). It is hepatically metabolized by cytochrome P-450, and there are known toxicities associated with high levels of this drug. The effects of ATRA can be potentiated by inhibition of cytochrome P-450, which is known to occur with certain drugs. We report a case of a patient with ATRA toxicity thought to be secondary to interaction with fluconazole.

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