Fundus lesions of adenomatous polyposis
Current Opinion in Ophthalmology, ISSN: 1040-8738, Vol: 10, Issue: 3, Page: 168-172
1999
- 31Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations31
- Citation Indexes31
- 31
- CrossRef21
- Captures13
- Readers13
- 13
Review Description
Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is the most frequent extraintestinal manifestation of familial adenomatous polyposis. Present in 70% of families with familiar adenomatous polyposis, CHRPE is a highly reliable and early marker of the disease. Studies over the past 5 years have addressed the histologic characteristics of the pigmented fundus lesions, the definition of universal positive fundus criteria, and mostly the genotype-phenotype correlation. Indeed, the position of the mutation site of the APC (adenomatous polyposis coli) gene on chromosome 5 influences the retinal expressivity because CHRPE is present only if the mutation is located between exons 9 and 15. In CHRPE-positive families, fundus examination is simple, noninvasive, reproducible, inexpensive, and allows early detection of the mutant gene carriers. Knowing the CHRPE status of patients in a family with familial adenomatous polyposis helps to identify constitutional APC mutations. The combination of genetic analysis and fundus examination offers a 100% diagnostic predictability.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032988403&origin=inward; http://dx.doi.org/10.1097/00055735-199906000-00003; http://www.ncbi.nlm.nih.gov/pubmed/10537774; http://journals.lww.com/00055735-199906000-00003; https://dx.doi.org/10.1097/00055735-199906000-00003; https://journals.lww.com/co-ophthalmology/Abstract/1999/06000/Fundus_lesions_of_adenomatous_polyposis.3.aspx
Ovid Technologies (Wolters Kluwer Health)
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