PlumX Metrics
Embed PlumX Metrics

Immunologic responses of HIV-1-infected study subjects to immunization with a mixture of peptide protein derivative-V3 loop peptide conjugates.

Journal of acquired immune deficiency syndromes (1999), ISSN: 1525-4135, Vol: 22, Issue: 5, Page: 467-76
1999
  • 2
    Citations
  • 0
    Usage
  • 0
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2
    • Citation Indexes
      2
      • CrossRef
        2

Article Description

V3 loop peptide sequences from several HIV-1 strains were covalently linked to purified protein derivative (PPD) of Mycobacterium tuberculosis. A mixture of PPD conjugates of V3 loop peptides from six different strains of HIV-1 induced a stronger antibody response than a single V3 peptide-conjugate administered to guinea pigs and humans. Sera from animals immunized with a PPD-six peptide-PPD conjugate neutralized multiple primary-isolate strains of HIV-1. Potent immune responses were noted only when animals were primed with bacillus Calmette-Guerin (BCG), PPD was covalently bound to the peptides, and PPD was used as the carrier protein. Based on these animal studies, an immunogen consisting of PPD-conjugated V3 loop peptides from five HIV-1 strains was tested in 7 HIV-1 seropositive PPD skin test positive study subjects. Vaccinees exhibited over time a uniform increase in neutralizing antibodies for both laboratory adapted and primary isolates of HIV-1, including strains from multiple clades. In 3 patients with baseline viral loads between 8000 and 12,000 RNA copies/ml, the viral load declined in 2 patients to <400 copies/ml and in 1 patient to 1200 copies/ml without concurrent administration of highly active antiretroviral therapy (HAART).

Bibliographic Details

Arye Rubinstein; Yaffa Mizrachi; Massimo Pettoello-Mantovani; Jack Lenz; Geng-Qi Liu; Yair Rubinstein; Harris Goldstein; Israel Yust; Michael Burke; Nurit Vardinon; Zvi Spirer; Stanley J. Cryz Jr.

Ovid Technologies (Wolters Kluwer Health)

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know