PlumX Metrics
Embed PlumX Metrics

Inflammation and tissues damage in crystal deposition diseases

Current Opinion in Rheumatology, ISSN: 1040-8711, Vol: 17, Issue: 3, Page: 314-318
2005
  • 31
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Purpose of review: The crystal-induced arthropathies are characterized by self-limiting episodes of acute inflammation and chronic tissue damage. This review summarizes recent advances in the understanding of the cellular responses to monosodium urate, calcium pyrophosphate dihydrate and basic calcium phosphate crystals. Resent findings: Factors such as the myeloid related proteins, endothelin-1 and the complement membrane attack complex have been recently identified as mediators of acute crystal-induced inflammation. In addition, signalling pathways involved in both acute inflammation and tissue damage in crystal arthropathies have been further clarified. The potential of macrophage-derived transforming growth factor β1 to play a key role in the resolution phase of acute gout has also been demonstrated. Summary: Recent work has provided new insights into the regulation of both acute and chronic articular responses to, inflammatory microcrystals. Further analysis of these responses may identify potential therapeutic targets for management of the crystal-induced arthropathies. © 2005 Lippincott Williams & Wilkins.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know