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The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ

Critical Care Medicine, ISSN: 0090-3493, Vol: 34, Issue: 7, Page: 1874-1882
2006
  • 184
    Citations
  • 0
    Usage
  • 98
    Captures
  • 3
    Mentions
  • 0
    Social Media
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Article Description

Although phytochemical curcumin has been shown to possess anti-inflammatory properties, it remains unknown whether this agent has any beneficial effects in sepsis. The purpose of this study was to demonstrate whether curcumin protects septic animals and, if so, whether activation of peroxisome proliferator-activated receptor (PPAR)-γ, an anti-inflammatory nuclear receptor, plays any role.

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