Radiochemotherapy followed by gemcitabine and capecitabine in extrahepatic bile duct cancer: A phase I/II trial
American Journal of Clinical Oncology: Cancer Clinical Trials, ISSN: 0277-3732, Vol: 29, Issue: 6, Page: 576-582
2006
- 16Citations
- 15Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations16
- Citation Indexes14
- 14
- CrossRef11
- Clinical Citations2
- PubMed Guidelines2
- Captures15
- Readers15
- 15
Conference Paper Description
OBJECTIVE: Both radiotherapy and chemotherapy with gemcitabine and capecitabine have efficacy in biliary cancer. Our aim was to determine the toxicity and efficacy of a postoperative regimen combining both treatment modalities in extrahepatic bile duct cancer. METHODS: Patients were eligible after surgery for extrahepatic bile duct adenocarcinoma. Surgery included resection of lymph node positive cancer, incomplete resections and diagnostic laparotomy in unresectable tumors. Patients received a fractionated radiotherapy of 49.6 Gy accompanied by gemcitabine once a week. After a 2-week rest, patients were treated with gemcitabine and capecitabine on a 3-week cycle. The treatment continued for 6 cycles in nonmeasurable disease or until disease progression or intolerable toxicity. RESULTS: There were 18 patients (resection/laparotomy 7/11) enrolled between August 2003 and April 2005. Radiotherapy was completed in all patients and a total of 66 cycles of chemotherapy was applied. Fatigue and nausea were the most common mild adverse events. Grade 3 and 4 toxicity was rare after resection but frequent in unresectable disease and consisted of fatigue, nausea, duodenal ulcer, cachexia, and cholangitis in 1, 2, 2, 4, and 4 patients, respectively. We observed a 50% disease stabilization rate in patients with measurable disease. Median overall survival was 7.9 months in patients with unresectable tumors. Median overall survival in patients after resection has not been reached at a median follow-up of 19.5 months. CONCLUSIONS: Radiochemotherapy using gemcitabine followed by gemcitabine and capecitabine is an active regimen with manageable toxicity after resection of extrahepatic bile duct cancer but has significant toxicity in unresectable disease. © 2006 Lippincott Williams & Wilkins, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33845496517&origin=inward; http://dx.doi.org/10.1097/01.coc.0000239167.17922.82; http://www.ncbi.nlm.nih.gov/pubmed/17148994; https://journals.lww.com/00000421-200612000-00010; https://dx.doi.org/10.1097/01.coc.0000239167.17922.82; https://insights.ovid.com/crossref?an=00000421-200612000-00010
Ovid Technologies (Wolters Kluwer Health)
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