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Comparison of dalteparin and enoxaparin for deep venous thrombosis prophylaxis in patients with spinal cord injury

American Journal of Physical Medicine and Rehabilitation, ISSN: 0894-9115, Vol: 82, Issue: 9, Page: 678-685
2003
  • 66
    Citations
  • 0
    Usage
  • 64
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    66
    • Citation Indexes
      59
    • Clinical Citations
      5
      • PubMed Guidelines
        5
    • Policy Citations
      2
      • Policy Citation
        2
  • Captures
    64

Article Description

Objective: To determine differences between dalteparin and enoxaparin in patients with spinal cord injury. Design: This prospective, randomized, open-label study was performed as a multiple hospital trial in a large urban setting. A total of 100 patients with acute (<3 mo) spinal cord injury were recruited. A total of 95 patients met all inclusion criteria. Fifty received enoxaparin, and 45 received dalteparin. Main outcome measures included deep venous thrombosis, bleeding, compliance, Short Form-12 Health Status Survey, satisfaction, and medication/labor costs. Patients were randomized to receive 30 mg of enoxaparin subcutaneously every 12 hr or 5000 IU of dalteparin subcutaneously once daily. Prophylaxis was continued for 3 mo for motor-complete and 2 mo for motor-incomplete patients. Results: Six percent of the patients developed deep venous thrombosis while receiving enoxaparin and 4% while receiving dalteparin (χ = 0.44, df = 1, P = 0.51). Four percent developed bleeding while receiving dalteparin and 2% while receiving enoxaparin (χ = 0.13, df = 1, P = 0.72). No differences were noted in compliance, health status, or most of the satisfaction measures. It was, however, noted that after being discharged home, the patients receiving enoxaparin rated the shots significantly more inconvenient (two injections per day) compared with taking three pills per day, than those receiving dalteparin (one injection per day, P < 0.05). The cost of the medication was $1101/mo for enoxaparin (two injections per day) and $750/mo for dalteparin (one injection per day). Conclusion: Similar compliance, health status, deep venous thrombosis, and bleeding rates were found between dalteparin and enoxaparin.

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