Vitamin D receptor immunohistochemistry variability in sun-exposed and non-sun-exposed melanomas
Melanoma Research, ISSN: 1473-5636, Vol: 27, Issue: 1, Page: 17-23
2017
- 14Citations
- 18Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations14
- Citation Indexes14
- 14
- CrossRef13
- Captures18
- Readers18
- 18
Article Description
Ultraviolet rays are one of the leading factors in the development of melanoma (MM); however, ultraviolet rays seem not to play a role in non-sun-exposed MM, where systemic immunosuppression, anatomical, and physiological features may contribute toward the development of the malignancy. Our aim was to evaluate Vitamin D receptor (VDR) expression in shield-site melanoma (ST-MM) and non-shield-site melanoma (NST-MM) to find features that could explain the different biological behavior of MM according to the area of onset. We reviewed 118 specimens of MM. VDR expression was assayed using immunohistochemistry by dividing the specimens according to the anatomical area. We included MM of the soles, feet, hands, gluteus, scrotum, skin of the penile shaft, and large vaginal labia in the ST-MM group. The NST-MM group was divided into two main categories: NST-MM of chronic sun-exposed areas, including MM of the face, scalp, neck, back of the hands, and NST-MM of intermittent sun-exposed areas, including MM of the trunk, lower, and upper limbs. In shield sites, 66.67% of MMs showed VDR expression; in intermittent sun-exposed areas, 33.3% showed VDR expression; and in chronic sun-exposed areas, only 4.66% showed VDR expression. A similar behavior was observed for Breslow's thickness, where VDR staining intensity was higher in thicker lesions, ranging between 60 and 100%. We found that VDR expression decreased from ST-MM to NST-MM. These findings confirm the hypothesis that different pathways are involved in ST-MM and NST-MM.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84992709420&origin=inward; http://dx.doi.org/10.1097/cmr.0000000000000311; http://www.ncbi.nlm.nih.gov/pubmed/27792059; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00008390-201702000-00003; https://journals.lww.com/00008390-201702000-00003; https://dx.doi.org/10.1097/cmr.0000000000000311; https://journals.lww.com/melanomaresearch/Abstract/2017/02000/Vitamin_D_receptor_immunohistochemistry.3.aspx
Ovid Technologies (Wolters Kluwer Health)
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