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Memantine reduces craving for alcohol in alcohol-induced dementia: A case report

Addictive Disorders and their Treatment, ISSN: 1531-5754, Vol: 8, Issue: 1, Page: 52-54
2009
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Article Description

People with alcohol dependence sometimes develop cognitive brain changes or dementia that limit the usefulness of benzodiazepines in detoxification. Memantine, an N-methyl-D-aspartate receptor channel blocker, is postulated to reverse the upregulation of N-methyl-D-aspartate receptor functions associated with prolonged heavy use of alcohol and has been shown to reduce alcohol craving. We report the case of a 65-year-old man with alcohol dependence, cognitive impairment, and persistent craving for alcohol after detoxification in whom craving and cognitive impairment were significantly improved on treatment with memantine. Copyright © 2009 by Lippincott Williams & Wilkins.

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