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Aging and osteoarthritis

Current Opinion in Rheumatology, ISSN: 1040-8711, Vol: 23, Issue: 5, Page: 492-496
2011
  • 214
    Citations
  • 0
    Usage
  • 278
    Captures
  • 1
    Mentions
  • 36
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    214
  • Captures
    278
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    36
    • Shares, Likes & Comments
      36
      • Facebook
        36

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Review Description

Purpose of Review: Osteoarthritis is strongly linked to aging but the mechanisms for this link are incompletely understood. The recent literature was reviewed to find studies providing new insights into the connection between aging and osteoarthritis. Recent Findings: Basic aging studies in nonarticular cells suggest that a cell stress or cell damage response contributes to chronic inflammation that promotes age-related diseases. This cellular response results in the senescence-associated secretory phenotype which has many of the characteristics of an osteoarthritic chondrocyte in terms of the cytokines, chemokines, and proteases produced. Oxidative stress can promote cell senescence and studies have shown a role for oxidative stress in altering cell signaling pathways in chondrocytes that can disrupt the response to growth factors. Mitochondria are an important source of reactive oxygen species and studies continue to support a role for the mitochondria in osteoarthritis, including work suggesting changes in energy production. Cell death occurs in osteoarthritic cartilage and recent studies suggest autophagy may play a role in determining if a cell lives or dies when stressed. Summary: Continued progress is being made on characterizing aging-related changes in cartilage. Additional studies are needed that focus on the tissues outside of the articular cartilage that play a role in osteoarthritis. Because osteoarthritis occurs in older adults who also have age-related changes in muscle, bone, fat, and the nervous system, it is likely that a more general and systemic approach will be needed to better understand the link between aging and osteoarthritis. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Bibliographic Details

Francisco Blanco; Ignacio Rego-Perez

Ovid Technologies (Wolters Kluwer Health)

Medicine

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