Host genetic determinants of HIV pathogenesis: An immunologic perspective
Current Opinion in HIV and AIDS, ISSN: 1746-630X, Vol: 3, Issue: 3, Page: 342-348
2008
- 14Citations
- 25Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations14
- Citation Indexes14
- 14
- CrossRef11
- Captures25
- Readers25
- 25
- Mentions1
- News Mentions1
- 1
Most Recent News
Examining the Role of Genetics in Determining the Immune Response to an HIV Vaccine in HIV-Uninfected Adult Twins
STUDY INFORMATION OFFICIAL TITLE: A Phase 1B Clinical Trial to Examine the Role of Host Genetics in Determining the Immune Response to HIV Vaccination (With
Review Description
PURPOSE OF REVIEW: The purpose of this review is to highlight recent advances in our understanding of host genetic determinants of HIV pathogenesis and to provide a theoretical framework for interpreting these studies in the context of our evolving understanding of HIV immunopathogenesis. RECENT FINDINGS: The first genome-wide association analysis of host determinants of HIV pathogenesis and other recent studies evaluating the interaction between killer cell immunoglobulin-like receptors and human leukocyte antigen alleles have implicated both adaptive and innate immune responses in the control of HIV replication. Furthermore, genetic variation associated with the expression of CCR5 and its ligand have been strongly associated with both decreased susceptibility to HIV infection and delayed clinical progression, independent of their effects on viral replication, suggesting a potential role for CCR5 inhibitors as immune-based therapies in HIV disease. SUMMARY: Host factors associated with the control of HIV replication may help identify important targets for vaccine design, while those associated with delayed clinical progression provide targets for future immune-based therapies against HIV infection. © 2008 Lippincott Williams & Wilkins, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=42049092144&origin=inward; http://dx.doi.org/10.1097/coh.0b013e3282fbaa92; http://www.ncbi.nlm.nih.gov/pubmed/19372988; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=01222929-200805000-00023; http://journals.lww.com/01222929-200805000-00023; https://dx.doi.org/10.1097/coh.0b013e3282fbaa92; https://insights.ovid.com/crossref?an=01222929-200805000-00023
Ovid Technologies (Wolters Kluwer Health)
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