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Risk of progression to hypertension across baseline blood pressure in nonhypertensive participants among rural Chinese adults: A prospective study

Journal of Hypertension, ISSN: 0263-6352, Vol: 28, Issue: 6, Page: 1158-1165
2010
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Article Description

Objectives: To assess the risk of progression to hypertension across baseline blood pressure (BP) level among rural Chinese adults. Methods: A population-based sample of 24 052 rural Chinese adults aged at least 35 years and free from hypertension at baseline were followed up from 2004-2006 to 2008. Incident hypertension was defined as SBP of at least 140 mmHg, DBP of at least 90 mmHg, current use of antihypertensive medication, or all. Results: During a median follow-up of 28 months, 26.5% participants developed clinical hypertension, most of which were untreated and uncontrolled. The cumulative incidence of hypertension in participants with optimal, normal, and high-normal BP was 21.2, 25.2, and 32.4%, respectively. The higher incidence of hypertension (per 100 person-years) was obviously observed in higher BP category at baseline among both older and younger groups (both P for trend <0.05). Compared with optimal BP, the adjusted hazard ratios of participants with normal and high-normal BP for incident hypertension were 1.16 (95% confidence interval 1.08-1.24) and 1.28 (95% confidence interval 1.20-1.36), respectively. In addition, older age, men, Mongolian ethnicity, alcohol drinking, family history of hypertension, BMI, and change in BMI during follow-up were also independently associated with incident hypertension. Conclusion: There was a stepwise increase in risk of progression to hypertension across baseline BP level. This information could help us define a population at high risk of progression to hypertension, to underscore the importance of frequent BP monitoring, and early interventions in rural Chinese adults. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Bibliographic Details

Zheng, Liqiang; Sun, Zhaoqing; Zhang, Xingang; Xu, Changlu; Li, Jiajin; Li, Meiqiong; Wang, Lidong; Li, Jue; Hu, Dayi; Sun, Yingxian

Ovid Technologies (Wolters Kluwer Health)

Medicine; Biochemistry, Genetics and Molecular Biology

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