Performance of interferon-γ release assay for the diagnosis of active or latent tuberculosis in children in the first 2 years of age: A multicenter study of the Italian society of pediatric infectious diseases
Pediatric Infectious Disease Journal, ISSN: 1532-0987, Vol: 33, Issue: 9, Page: E226-E231
2014
- 33Citations
- 54Captures
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Metrics Details
- Citations33
- Citation Indexes32
- 32
- CrossRef25
- Policy Citations1
- 1
- Captures54
- Readers54
- 45
Article Description
Background: The diagnosis of latent or active tuberculosis in children is often challenging. Recently, interferon-γ release assays have been licensed, but their diagnostic accuracy in young children remains questionable as frequent false-negative or indeterminate results have been reported. Methods: We performed a multicenter, retrospective study in children 0-24 months of age who were tested at least once with QuantiFERON-TB Goldin-tube (QTF-IT) ± tuberculin skin test (TST), to analyze its use and performance in clinical practice. Results: Eight-hundred and twenty-three children (449 males, median age 13.5 months) were enrolled. QTF-IT sensitivity and specificity for active tuberculosis were 92.4% and 98.6%, respectively. Indeterminate tests (4.2 %) were not related to age (P = 0.838) or gender (P = 0.223); 32 children (91.4 %) with an indeterminate QTF-IT ultimately resulted uninfected. In the 616 subjects with valid paired results of QTF-IT and TST, sensitivity and specificity were comparable (91.1% vs. 85.1% and 98.1% vs. 97.9%, respectively). Diagnostic concordance between tests was higher in Bacillus Calmétte-Guerin nonvaccinated children (κ = 0.802). A high rate of discordant tests was observed in latent infections. Conclusions: QTF-IT showed good sensitivity and specificity, and a low rate of indeterminate results in the first 2 years of life, supporting its use at this age. However, considering costs and the similar performance between QTF-IT and TST, it is reasonable to suggest the latter as first-line testing in young children. The complementary use of TST and interferon-γ release assays may be considered in selected cases to improve the accuracy of testing.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84965125711&origin=inward; http://dx.doi.org/10.1097/inf.0000000000000353; http://www.ncbi.nlm.nih.gov/pubmed/25361032; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00006454-201409000-00011; https://journals.lww.com/00006454-201409000-00011; https://dx.doi.org/10.1097/inf.0000000000000353; https://insights.ovid.com/article/00006454-201409000-00011
Ovid Technologies (Wolters Kluwer Health)
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