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Pharmacokinetics of Polymyxin B in an Infant With Multidrug-resistant Klebsiella pneumoniae Bacteremia

The Pediatric Infectious Disease Journal, ISSN: 0891-3668, Vol: 30, Issue: 6, Page: 537-539
2011
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Metric Options:   Counts1 Year3 Year

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Article Description

We report our experience with a 9-month-old infant treated with intravenous polymyxin B for multidrug-resistant Klebsiella pneumoniae bacteremia. Serial blood samples were obtained at steady state and serum drug concentrations were determined using a validated liquid chromatography-mass spectrometry method. The elimination half-lives of polymyxin B1 and isoleucine-polymyxin B1 were found to be 3.1 and 4.7 hours, respectively.

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