PlumX Metrics
Embed PlumX Metrics

Value of Factor V in the Diagnosis of Early Graft Dysfunction After Liver Transplantation. Internal Validation.

Liver Transplantation, ISSN: 1527-6473
2024
  • 0
    Citations
  • 0
    Usage
  • 1
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    1
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Regional University Hospital Malaga Researcher Has Provided New Data on Blood Coagulation Factors (Value of Factor V in the diagnosis of early graft dysfunction after liver transplantation: Internal validation)

2024 NOV 11 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Research findings on blood coagulation factors are discussed in

Article Description

Primary graft dysfunction is a major early complication following liver transplantation, potentially leading to retransplantation or patient death. Coagulation Factor V and ALT have emerged as important biomarkers in assessing liver function, yet their role as early predictors of graft loss has not been fully validated. The aim of this study is to conduct an internal validation of published results on the applicability of Factor V and ALT for diagnosing graft dysfunction and its predictive ability for graft loss within the first 90 days. We conducted a retrospective cohort study including 513 adult recipients from 2012 to 2023 at the Regional University Hospital of Málaga. Factor V and ALT levels were measured on postoperative day 2 and patients were categorized based on FV <37.5 and ALT >1539. The association with 90-day graft loss was analysed. Graft loss occurred in 43 patients (8.4%) within the first 90 days. The combination of FV <37.5 and ALT >1539 on postoperative day 2 demonstrated a specificity of 99% and a test efficiency of 94% in predicting graft loss. Patients meeting both criteria had a 74-fold increased risk of graft loss, with most losses occurring within the first week, and a median survival of 4 days. These findings suggest that Factor V and ALT on postoperative day 2 are reliable early markers for predicting graft loss, enabling risk stratification and guiding critical decisions regarding early retransplantation in the immediate postoperative period.

Bibliographic Details

Sanchez-Gonzalez, Claudia; Fernández Aguilar, José L; Sánchez Pérez, Belinda; Santoyo Santoyo, Julio

Ovid Technologies (Wolters Kluwer Health)

Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know