Energetics and metabolism in the failing heart: Important but poorly understood
Current Opinion in Clinical Nutrition and Metabolic Care, ISSN: 1363-1950, Vol: 13, Issue: 4, Page: 458-465
2010
- 36Citations
- 59Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef35
- Captures59
- Readers59
- 59
Review Description
Purpose of review: Profound abnormalities in myocardial energy metabolism occur in heart failure and correlate with clinical symptoms and survival. Available comprehensive human metabolic data come from small studies, enrolling patients across heart failure causes, at different disease stages, and using different methodologies, and is often contradictory. Remaining fundamental gaps in knowledge include whether observed shifts in cardiac substrate utilization are adaptive or maladaptive, causal or an epiphenomenon of heart failure. Recent findings: Recent studies have characterized the temporal changes in myocardial substrate metabolism involved in progression of heart failure, the role of insulin resistance, and the mechanisms of mitochondrial dysfunction in heart failure. The concept of metabolic inflexibility has been proposed to explain the lack of energetic and mechanical reserve in the failing heart. Summary: Despite current therapies, which provide substantial benefits to patients, heart failure remains a progressive disease, and new approaches to treatment are necessary. Developing metabolic interventions would be facilitated by systems-level integration of current knowledge on myocardial metabolic control. Although preliminary evidence suggests that metabolic modulators inducing a shift towards carbohydrate utilization seem generally beneficial in the failing heart, such interventions should be matched to the stage of metabolic deregulation in the progression of heart failure. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954348958&origin=inward; http://dx.doi.org/10.1097/mco.0b013e32833a55a5; http://www.ncbi.nlm.nih.gov/pubmed/20453645; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00075197-201007000-00020; http://journals.lww.com/00075197-201007000-00020; https://dx.doi.org/10.1097/mco.0b013e32833a55a5; https://insights.ovid.com/crossref?an=00075197-201007000-00020
Ovid Technologies (Wolters Kluwer Health)
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