LncRNA MCM3AP-AS1 is downregulated in atherosclerosis and sponges miR-448 to suppress vascular smooth muscle cell proliferation
Medicine (United States), ISSN: 1536-5964, Vol: 102, Issue: 22, Page: E33731-null
2023
- 3Citations
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Most Recent News
New Atherosclerosis Study Findings Have Been Reported by Investigators at Ganzhou People's Hospital (Lncrna Mcm3ap-as1 Is Downregulated In Atherosclerosis and Sponges Mir-448 To Suppress Vascular Smooth Muscle Cell Proliferation)
2023 JUL 18 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Cardiovascular Daily -- Researchers detail new data in Cardiovascular Diseases and Conditions
Article Description
Long noncoding RNA MCM3AP-AS1 plays critical roles in cancers, but its role in atherosclerosis is yet to be elucidated. The expression of MCM3AP-AS1 in atherosclerosis and control plasma samples were measured by RT-qPCR. IntaRNA was used to predict potential base pairings between MCM3AP-AS1 and miR-448, and the results were confirmed by a dual luciferase activity assay. Cell proliferation assay was performed to explore the role of overexpression of MCM3AP-AS1, miR-448, and myocyte enhancer factor 2 (MEF2)-C in the proliferation of human aortic smooth muscle cells (HAOSMCs). MCM3AP-AS1 was downregulated in atherosclerosis and directly interacted with miR-448, which is a critical player in the proliferation of HAOSMCs, indicating its involvement in atherosclerosis. However, MCM3AP-AS1 and miR-448 showed no role in regulating the expression of each other. In contrast, overexpression of MCM3AP-AS1 increased the expression levels of MEF2-C, which can be targeted by miR-448. Moreover, MCM3AP-AS1 was found to inhibit the effects of miR-448 overexpression on both HAOSMC proliferation and MEF2-C expression. MCM3AP-AS1 is downregulated in atherosclerosis and sponges miR-448 to suppress the proliferation of HAOSMCs.
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Ovid Technologies (Wolters Kluwer Health)
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