PlumX Metrics
Embed PlumX Metrics

Reassessing the role of liver transplantation for patients with metastatic colorectal cancer to the liver

Current Opinion in Organ Transplantation, ISSN: 1531-7013, Vol: 24, Issue: 2, Page: 118-120
2019
  • 1
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Purpose of reviewEarly studies reported poor survival rates following liver transplantation for metastatic colorectal cancer to the liver and liver transplantation has thus traditionally been contraindicated for these patients. However, improvements in liver transplantation outcomes, immunosuppression and the treatment of colorectal cancer warrant a reassessment of the role of liver transplantation for metastatic colorectal cancer.Recent findingsThe literature on this topic is sparse, the majority of publications being isolated cases of liver transplantation for patients with metastatic colorectal cancer to the liver. These case reports are heterogeneous, as patients received varying chemotherapy regimens and liver transplantation was performed at different times and for different indications. A prospective clinical trial out of Norway, however, has recently reported 5-year survival of 60% in a cohort of 21 patients undergoing liver transplantation for metastatic colorectal cancer to the liver. These results are significantly better than standard of care chemotherapy and comparable with outcomes for other indications for liver transplantation.SummaryThe role of liver transplantation for patients with metastatic colorectal cancer to the liver needs to be further elucidated and defined by ongoing clinical trials and experience with living donor liver transplantation.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know