Correlation of DOTATOC Uptake and Pathologic Grade in Neuroendocrine Tumors
Pancreas, ISSN: 1536-4828, Vol: 48, Issue: 7, Page: 948-952
2019
- 15Citations
- 11Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations15
- Citation Indexes14
- 14
- CrossRef11
- Policy Citations1
- Policy Citation1
- Captures11
- Readers11
- 11
Article Description
Objectives Gallium (Ga)-DOTATOC is a somatostatin analog used to detect neuroendocrine tumors (NETs). Ki-67 proliferation index (Ki-67 PI) has been established as a prognostic factor in NETs. We aimed to evaluate whether a correlation exists between Ki-67 PI and somatostatin receptor positron emission tomography (SSTR-PET) uptake. Methods We retrospectively reviewed 238 DOTATOC PET scans between 2014 and 2016. Patients were excluded if DOTATOC PET was performed more than 365 days from the date of biopsy. Maximum standardized uptake values (SUV) of SSTR-PET from biopsied lesions were measured and correlated with Ki-67 PI using the Pearson correlation coefficient. Results Among 110 lesions from 90 patients, DOTATOC PET had 92.7% sensitivity and 100% specificity (102 true positives, 8 false negatives) for detection of NETs. Among 63 lesions from 54 patients with Ki-67 PI available, there were 27 grade 1 lesions [median Ki-67 PI, 1.0%; interquartile range (IQR), 1.0-2.0], 30 grade 2 lesions (median, Ki-67 PI 7.5%; IQR, 5-10), and 6 grade 3 lesions (median Ki-67 PI, 30%; IQR, 26-34). There was a correlation between Ki-67 PI and SUV (r = -0.3, P = 0.018). Conclusions Our analysis demonstrates an inverse correlation between Ki-67 PI and SUV in NETs. Somatostatin receptor-PET provides additional information that can help guide management of NETs.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069505057&origin=inward; http://dx.doi.org/10.1097/mpa.0000000000001356; http://www.ncbi.nlm.nih.gov/pubmed/31268975; https://journals.lww.com/00006676-201908000-00014; https://dx.doi.org/10.1097/mpa.0000000000001356; https://journals.lww.com/pancreasjournal/Abstract/2019/08000/Correlation_of_DOTATOC_Uptake_and_Pathologic_Grade.14.aspx
Ovid Technologies (Wolters Kluwer Health)
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