Acute ibuprofen intoxication: Report on a case and review of the literature
American Journal of Forensic Medicine and Pathology, ISSN: 0195-7910, Vol: 33, Issue: 3, Page: 242-246
2012
- 14Citations
- 63Captures
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Metrics Details
- Citations14
- Citation Indexes14
- 14
- CrossRef10
- Captures63
- Readers63
- 51
- 12
Article Description
A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt.Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 μg/mL; gastric content was 200 μg/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature. Copyright © 2012 by Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865464096&origin=inward; http://dx.doi.org/10.1097/paf.0b013e318253d6ff; http://www.ncbi.nlm.nih.gov/pubmed/22835967; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00000433-201209000-00013; http://journals.lww.com/00000433-201209000-00013; https://dx.doi.org/10.1097/paf.0b013e318253d6ff; https://journals.lww.com/amjforensicmedicine/Abstract/2012/09000/Acute_Ibuprofen_Intoxication__Report_on_a_Case_and.13.aspx
Ovid Technologies (Wolters Kluwer Health)
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