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Acute ibuprofen intoxication: Report on a case and review of the literature

American Journal of Forensic Medicine and Pathology, ISSN: 0195-7910, Vol: 33, Issue: 3, Page: 242-246
2012
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Article Description

A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt.Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 μg/mL; gastric content was 200 μg/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature. Copyright © 2012 by Lippincott Williams & Wilkins.

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