Napsin A expression in anaplastic, poorly differentiated, and micropapillary pattern thyroid carcinomas
American Journal of Surgical Pathology, ISSN: 0147-5185, Vol: 37, Issue: 8, Page: 1215-1222
2013
- 36Citations
- 24Captures
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Metrics Details
- Citations36
- Citation Indexes36
- CrossRef36
- 33
- Captures24
- Readers24
- 24
Article Description
Napsin A is a sensitive and specific marker for pulmonary adenocarcinoma versus squamous cell carcinoma. However, studies have shown that napsin A is also positive in approximately 5% of papillary thyroid carcinomas. The prevalence of napsin A in more aggressive types of thyroid carcinoma is unknown. Napsin A positivity in metastatic thyroid carcinoma, especially in conjunction with thyroid transcription factor-1 (TTF-1), could be misdiagnosed as lung adenocarcinoma. We investigated napsin A, TTF-1, and PAX8 expression in 26 anaplastic, 16 poorly differentiated, and 2 micropapillary pattern thyroid carcinomas. A focal micropapillary component was also present in 3 poorly differentiated and 3 anaplastic thyroid carcinomas. Four of 26 (15%) anaplastic, 2/16 (13%) poorly differentiated, and 2/2 (100%) micropapillary pattern thyroid carcinomas were napsin A positive. Three of the 6 cases (50%) with a focal micropapillary component were napsin A positive (1 of these 3 cases was positive only in the micropapillary component). All napsin A-positive cases were also positive for TTF-1, and all but 1 micropapillary pattern carcinoma were also PAX8 positive. In 1 case, napsin A was positive in the micropapillary component, but PAX8 was only positive in the adjacent poorly differentiated carcinoma. In summary, a minority of anaplastic and poorly differentiated thyroid carcinomas are napsin A positive. More importantly, napsin A expression is more common in carcinomas with a micropapillary component, a pattern shared in common with some lung adenocarcinomas. PAX8 may be diagnostically useful to distinguish these napsin A-positive thyroid carcinomas from lung adenocarcinomas, which are PAX8 negative. © 2013 Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880572230&origin=inward; http://dx.doi.org/10.1097/pas.0b013e318283b7b2; http://www.ncbi.nlm.nih.gov/pubmed/23681073; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00000478-201308000-00011; https://journals.lww.com/00000478-201308000-00011; https://dx.doi.org/10.1097/pas.0b013e318283b7b2; https://insights.ovid.com/article/00000478-201308000-00011
Ovid Technologies (Wolters Kluwer Health)
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