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Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, ISSN: 1538-7151, Vol: 44, Issue: 1, Page: 37-41
2025
  • 1
    Citations
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    Usage
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    Captures
  • 1
    Mentions
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    Social Media
Metric Options:   Counts1 Year3 Year

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  • Citations
    1
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Study Findings from Royal Victoria Infirmary Provide New Insights into Carcinomas (Human Papillomavirus-associated Multiphenotypic Carcinoma: First Description of a Vulval Case)

2025 JAN 06 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Daily -- New research on Oncology - Carcinomas is the subject

Article Description

Human papillomavirus (HPV)-associated multiphenotypic sinonasal carcinoma is a rare and recently described epithelial neoplasm exhibiting myoepithelial differentiation and morphological overlap with salivary gland neoplasms, especially adenoid cystic carcinoma; it is commonly associated with HPV, especially type 33. It has mainly been reported in the nasal cavity and paranasal sinuses with a single case reported in the breast. Herein, we report the first vulval example in a 47-year-old patient who presented with a large craggy mass in the region of the Bartholin gland. The histologic features were of a high-grade carcinoma composed of basaloid cells arranged in sheets and nests, with occasional ductal formations, surrounded by densely hyalinised basement membrane-type material. There was diffuse block-type immunoreactivity with p16 and HPV genotyping revealed high-risk HPV type 16. In reporting this case, we highlight the propensity for "salivary gland-type" neoplasms to arise in the vulva, especially in the Bartholin gland, and stress that pathologists should consider salivary-type neoplasms when faced with a morphologically unusual vulval tumor.

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