Abacavir use and risk of recurrent myocardial infarction
AIDS, ISSN: 1473-5571, Vol: 32, Issue: 1, Page: 79-88
2018
- 20Citations
- 38Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations20
- Citation Indexes18
- 18
- CrossRef11
- Policy Citations2
- 2
- Captures38
- Readers38
- 38
Article Description
Objective: To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI. Design: International multicohort collaboration with follow-up from 1999 to 2016. Methods: The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 1 February 2016 or 6 months after last clinic visit. Poisson regression models considered associations between recurrent MI and exposure to ABC (use at index MI, current post-MI exposure and cumulative exposure), before and after adjusting for calendar year. Results: The 984 individuals who experienced an index MI during the study (91.3% male, median age 51 at index MI) were followed for 5312 person-years, over which time there were 136 recurrent MIs (rate 2.56/100 person-years, 95% confidence interval 2.13-2.99). Rates were 2.40 (1.71-3.09) and 2.65 (2.10-3.21)/100 person-years in those who were and were not on ABC, respectively, at the index MI, and 2.90 (2.01-3.78) and 2.44 (1.95-2.93)/100 person-years in those who were and were not currently receiving ABC, respectively, post-MI. No association was seen with recurrent MI and either cumulative exposure to ABC [relative rate 0.86 (0.68-1.10)/5 years], receipt of ABC at index MI [0.90 (0.63-1.29)] nor recent post-MI exposure to ABC [1.19 (0.82-1.71)]. Conclusion: Among people with a previous MI, there was no evidence for an association between use of ABC post-MI and an elevated risk of a recurrent MI.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85037378814&origin=inward; http://dx.doi.org/10.1097/qad.0000000000001666; http://www.ncbi.nlm.nih.gov/pubmed/29028664; https://journals.lww.com/00002030-201801020-00009; http://Insights.ovid.com/crossref?an=00002030-201801020-00009; https://dx.doi.org/10.1097/qad.0000000000001666; https://journals.lww.com/aidsonline/Fulltext/2018/01020/Abacavir_use_and_risk_of_recurrent_myocardial.9.aspx
Ovid Technologies (Wolters Kluwer Health)
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