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F-THK5351 PET Can Evaluate Tumor Extension in Intravascular Large B-Cell Lymphoma: Comparison with 11C-Methionine PET and 18F-FDG PET

Clinical Nuclear Medicine, ISSN: 1536-0229, Vol: 48, Issue: 4, Page: E204-E206
2023
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Metric Options:   Counts1 Year3 Year

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Findings from Department of Neurology Update Understanding of B-Cell Lymphoma (F-18-thk5351 Pet Can Evaluate Tumor Extension In Intravascular Large B-cell Lymphoma Comparison With C-11-methionine Pet and F-18-fdg Pet)

2023 APR 18 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Hematology Daily -- Fresh data on Oncology - B-Cell Lymphoma are presented

Article Description

A 79-year-old man presenting with gait disturbance and cognitive decline was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by random skin biopsy. Some IVLBCL lesions were identified by PET examinations using 11C-methionine, 18F-FDG, and 18F-THK5351. 11C-methionine and 18F-FDG uptake, which likely reflects the presence of the lymphoma cells themselves, increased clearly in the left putamen but weakly in the left deep white matter. 18F-THK5351 uptake increased in all lesions, likely reflecting perivascular astrogliosis caused by IVLBCL. Hence, 18F-THK5351 PET can evaluate tumor extension in IVLBCL lesions where 11C-methionine and 18F-FDG PET may fail in its visualization.

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