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Exploring the FAP-Targeted Therapeutics for Adrenocortical Carcinoma: Choosing the Right Track

Clinical Nuclear Medicine, ISSN: 1536-0229, Vol: 50, Issue: 3, Page: e160-e163
2025
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    1
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Study Results from Postgraduate Institute of Medical Education and Research Provide New Insights into Adrenocortical Carcinoma (Exploring the FAP-Targeted Therapeutics for Adrenocortical Carcinoma)

2024 NOV 21 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- A new study on adrenocortical carcinoma is now available.

Article Description

Metastatic or recurrent adrenocortical carcinoma is a potentially lethal malignancy, presenting significant challenges in disease management owing to absence of effective systemic treatments. Significantly diminished survival rates necessitate rapid identification of specific molecules for the development of targeted therapeutics. Fibroblast activation protein (FAP)-expressing cancer-associated fibroblasts have been a major breakthrough causing a paradigm shift in targeted theranostics focusing on the tumor microenvironment. The effectiveness of various FAP inhibitors (FAPis) and FAP targeting peptide has been extensively documented in diverse clinical investigations. We have evaluated 3 molecules, that is, DOTA.SA.FAPi (SA.FAPi), FAPi46, and FAP2286, as potential theranostic probes for adrenocortical carcinoma.

Bibliographic Details

Chopra, Sejal; Walia, Rama; Kaur, Komalpreet; Roesch, Frank; Moon, Euy Sung; Mittal, Bhagwant Rai; Shukla, Jaya

Ovid Technologies (Wolters Kluwer Health)

Medicine

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