Neoadjuvant S-1 With Concurrent Radiotherapy Followed by Surgery for Borderline Resectable Pancreatic Cancer: A Phase II Open-label Multicenter Prospective Trial (JASPAC05)
Annals of Surgery, ISSN: 1528-1140, Vol: 276, Issue: 5, Page: E510-E517
2022
- 32Citations
- 24Captures
- 1Mentions
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef30
- Captures24
- Readers24
- 18
- Mentions1
- News Mentions1
- 1
Most Recent News
Studies from National Cancer Center Hospital East in the Area of Pancreatic Cancer Reported [Neoadjuvant S-1 With Concurrent Radiotherapy Followed By Surgery for Borderline Resectable Pancreatic Cancer a Phase Ii Open-label Multicenter ...]
2022 NOV 16 (NewsRx) -- By a News Reporter-Staff News Editor at Japan Daily Report -- Research findings on Oncology - Pancreatic Cancer are discussed
Article Description
Objective: This study assessed whether neoadjuvant chemoradiotherapy (CRT) with S-1 increases the R0 resection rate in BRPC. Summary of Background Data: Although a multidisciplinary approach that includes neoadjuvant treatment has been shown to be a better strategy for BRPC than upfront resection, a standard treatment for BRPC has not been established. Methods: A multicenter, single-arm, phase II study was performed. Patients who fulfilled the criteria for BRPC received S-1 (40 mg/m2 bid) and concurrent radiotherapy (50.4 Gy in 28 fractions) before surgery. The primary endpoint was the R0 resection rate. At least 40 patients were required, with a 1-sided α = 0.05 and β = 0.05 and expected and threshold values for the primary endpoint of 30% and 10%, respectively. Results: Fifty-two patients were eligible, and 41 were confirmed to have definitive BRPC by a central review. CRT was completed in 50 (96%) patients and was well tolerated. The rate of grade 3/4 toxicity with CRT was 43%. The R0 resection rate was 52% among the 52 eligible patients and 63% among the 41 patients who were centrally confirmed to have BRPC. Postoperative grade III/IV adverse events according to the Clavien-Dindo classification were observed in 7.5%. Among the 41 centrally confirmed BRPC patients, the 2-year overall survival rate and median overall survival duration were 58% and 30.8 months, respectively. Conclusions: S-1 and concurrent radiotherapy seem to be feasible and effective at increasing the R0 resection rate and improving survival in patients with BRPC.
Bibliographic Details
Ovid Technologies (Wolters Kluwer Health)
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