Superiority of bone marrow-derived dendritic cells over monocyte-derived ones for the expansion of regulatory T cells in the Macaque
Transplantation, ISSN: 0041-1337, Vol: 85, Issue: 9, Page: 1351-1356
2008
- 26Citations
- 18Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations26
- Citation Indexes26
- 26
- CrossRef22
- Captures18
- Readers18
- 18
Article Description
Regulatory T cells (Treg) have been identified as playing a pivotal role in the control of tolerance and in the suppression of pathologic immune responses in autoimmune diseases, transplantation, and graft-versus-host disease. Treg expanded ex vivo by dendritic cells could be potential reagents to promote antigen-specific tolerance in vivo. However, in vivo studies have been carried out mostly in rodents and will need validation in primates before clinical application. We characterized macaque dendritic cell derived either from bone marrow with and without prior CD34 cell selection (BMDC), or from CD14 peripheral blood mononuclear cells (Mo-DC). We demonstrate that with a semi-mature phenotype, BMDC are superior to Mo-DC in their capacity to expand freshly isolated allogeneic macaque CD4CD25CD127Foxp3Treg in vitro in the presence of interleukin-2. Moreover, the expanded Treg maintain their phenotype and suppressive activity. These data provide a step toward the use of macaque dendritic cell to expand Treg for future preclinical testing. © 2008 Lippincott Williams & Wilkins, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=43449136472&origin=inward; http://dx.doi.org/10.1097/tp.0b013e31816f22d6; http://www.ncbi.nlm.nih.gov/pubmed/18475195; https://journals.lww.com/00007890-200805150-00022; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00007890-200805150-00022; https://dx.doi.org/10.1097/tp.0b013e31816f22d6; https://insights.ovid.com/ShowUpgradeBrowserMessage
Ovid Technologies (Wolters Kluwer Health)
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