The metabotropic glutamate mGluR5 receptor agonist CHPG stimulates food intake
NeuroReport, ISSN: 0959-4965, Vol: 21, Issue: 10, Page: 704-708
2010
- 20Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef7
- Captures26
- Readers26
- 26
Article Description
The metabotropic glutamate receptor 5 (mGluR5) has been suggested to modulate energy balance. For example, mGluR5 antagonists inhibit food intake in rodents and mGluR5 knockout mice resist diet-induced obesity. However, nonspecific effects can reduce food intake. Thus, to further support the role of mGluR5 in feeding behaviour, we evaluated if the mGluR5 agonist (R,S)-2-chloro-5-hydroxyphenylglycine (CHPG) would induce the opposite effect, i.e. increased food intake in rats. Intracerebroventricularly injected CHPG (0.5-1.5 μmol) induced a dose-dependent stimulation of food intake (349% increase at 2 h with 1.5 μmol). The mGluR5 antagonist 3-[(2-methyl-1,3- thiazol-4-yl)ethynyl]-pyridine (10 mg/kg intraperitoneally) reduced 24 h food intake, without altering CHPG-induced feeding. These findings further support a physiologically relevant role of mGluR5 in appetite regulation. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954033495&origin=inward; http://dx.doi.org/10.1097/wnr.0b013e32833b4fe7; http://www.ncbi.nlm.nih.gov/pubmed/20505551; https://journals.lww.com/00001756-201007140-00008; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00001756-900000000-99768; https://dx.doi.org/10.1097/wnr.0b013e32833b4fe7; https://journals.lww.com/neuroreport/toc/9000/00000
Ovid Technologies (Wolters Kluwer Health)
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