Assessing health-related quality of life in generalized anxiety disorder using the Quality of Life Enjoyment and Satisfaction Questionnaire
International Clinical Psychopharmacology, ISSN: 0268-1315, Vol: 24, Issue: 6, Page: 289-295
2009
- 43Citations
- 58Captures
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Metrics Details
- Citations43
- Citation Indexes42
- 42
- CrossRef29
- Policy Citations1
- Policy Citation1
- Captures58
- Readers58
- 58
Review Description
Generalized anxiety disorder (GAD) is a chronic illness that leads to substantial impairments in quality of life. This post-hoc analysis used combined data from three 8-week quetiapine extended-release trials to investigate the reliability, validity, and responsiveness of the Short Form of the Quality of Life Enjoyment and Satisfaction Questionnaire [Q-LES-Q (SF)] in 2588 patients with GAD. The baseline Q-LES-Q (SF) score showed a Cronbach's α value of 0.86, indicative of reliability. Validity analyses for Q-LES-Q (SF) identified significant correlations with clinical efficacy measures (r>0.34 at week 8; P<0.001) and significant discrimination between patient groups categorized by symptom severity (P<0.001). Responsiveness was shown by significant differences in mean changes in Q-LES-Q (SF) scores at week 8 between patients defined according to the Hamilton Rating Scale for Anxiety response or remission criteria (P< 0.001). The minimum clinically important Q-LES-Q (SF) score change was identified to be 6.80 points. Using this definition, response rates were significantly greater with quetiapine extended-release 150mg versus placebo in individual trials and the combined population (P ≤ 0.02). This analysis shows the overall reliability, validity, and responsiveness of the Q-LES-Q (SF) as a measure of overall quality of life and satisfaction in patients with GAD. © 2009 Wolters Kluwer Health, Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=73949106511&origin=inward; http://dx.doi.org/10.1097/yic.0b013e32832d6bf4; http://www.ncbi.nlm.nih.gov/pubmed/19707153; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00004850-200911000-00002; http://journals.lww.com/00004850-200911000-00002; https://dx.doi.org/10.1097/yic.0b013e32832d6bf4; https://journals.lww.com/intclinpsychopharm/Abstract/2009/11000/Assessing_health_related_quality_of_life_in.2.aspx
Ovid Technologies (Wolters Kluwer Health)
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