The Florey Lecture, 1990. How is the cell division cycle regulated?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, ISSN: 0962-8436, Vol: 332, Issue: 1264, Page: 271-276
1991
- 20Citations
- 20Captures
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- Citations20
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- 20
- CrossRef13
- Captures20
- Readers20
- 19
Review Description
It is argued in this lecture that in most eukaryotic cells onset of mitosis is coupled to attainment of a critical cell mass and to completion of the previous S-phase. In fission yeast these controls operate through a regulatory gene network that activates the p34cdc2 protein kinase at mitosis. This is brought about by dephosphorylation of a tyrosine residue located in the ATP binding site of the kinase. The p34cdc2 protein kinase is also important for regulating the onset of mitosis in vertebrate cells suggesting that there is a universal control regulating mitosis in all eukaryotic cells.
Bibliographic Details
The Royal Society
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