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Mycobacterium arosiense sp. nov., a slowly growing, scotochromogenic species causing osteomyelitis in an immunocompromised child

International Journal of Systematic and Evolutionary Microbiology, ISSN: 1466-5026, Vol: 58, Issue: 10, Page: 2398-2402
2008
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Article Description

A yellow-pigmented, scotochromogenic, slowly growing mycobacterial strain, designated T1921, was isolated from the disseminated osteomyelitic lesions of a 7-year-old child with an underlying partial gamma interferon receptor alpha-1 deficiency. Hybridization by the line probe assay indicated the presence of a Mycobacterium species. Sequencing of the 16S rRNA gene, the internally transcribed spacer (ITS) region and the hsp65 and rpoB genes revealed that strain T1921 could be differentiated from all recognized species of the genus Mycobacterium. Phylogenetic analysis based on the 16S rRNA gene indicated that strain T1921 was related most closely to Mycobacterium intracellulare, whereas analysis based on the ITS and hsp65 and rpoB genes indicated that it was most closely plated to Mycobacterium avium. Phenotypic tests were not able to differentiate strain T1921 from similar slowly gVowing mycobacteria. Strain T1921 is considered to represent a novel species of the genus Mycobacterium, for which the, name Mycobacterium arosiense sp. nov. is proposed. The type strain is T1921 (=DSM 45069T =ATCC BAA-1401. © 2008 IUMS.

Bibliographic Details

Bang, Didi; Herlin, Troels; Stegger, Marc; Andersen, Aase Bengaard; Torkko, Pirjo; Tortoli, Enrico; Thomsen, Vibeke Ostergaard

Microbiology Society

Immunology and Microbiology; Agricultural and Biological Sciences

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