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Serological relationship between cutaneous human papillomavirus types 5, 8 and 92

Journal of General Virology, ISSN: 0022-1317, Vol: 90, Issue: 1, Page: 136-143
2009
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Article Description

Evidence of a possible association of cutaneous human papillomavirus (HPV) types, especially members of the genus Betapapillomavirus, and the development of non-melanoma skin cancer (NMSC) is accumulating. Vaccination with virus-like particles (VLPs) consisting of self-assembled L1, the major capsid protein, has been introduced to control anogenital HPV infection. This study examined the serological relationship between betapapillomavirus (β-PV) types 5 and 8 and the new type HPV-92, which has recently been isolated from a basal cell carcinoma containing a high number of viral genomes. Following expression by recombinant baculoviruses, the L1 protein of HPV-92 self-assembled into VLPs that elicited high-titre antibodies after immunization, similar to VLPs from HPV-5 and -8. Haemagglutination inhibition (HAI) assays were used as a surrogate method for the detection of virion-neutralizing antibodies, which correlates with protection from infection. Antisera raised against HPV-5 and -8 VLPs displayed HAI activity not only against the homologous type, but also against heterologous HPV types 5, 8 and 92, whereas HAI activity of antisera against HPV-92 VLP was restricted to the homologous type. The results of neutralization assays using HPV-5 pseudovirions were consistent with those from HAI assays. Cross-neutralizing immune responses by VLP vaccination against heterologous HPV types may provide broader protection against the multiplicity of HPV types detected in NMSC. If a close link to HPV infection can be conclusively established, these results may provide a basis for further evaluation of VLPs of β-PVs as candidates for a prophylactic skin-type HPV vaccine, aimed at reducing the incidence of NMSC. © 2009 SGM.

Bibliographic Details

Handisurya, Alessandra; Gambhira, Ratish; Schellenbacher, Christina; Shafti-Keramat, Saeed; Forslund, Ola; Favre, Michel; Kirnbauer, Reinhard

Microbiology Society

Immunology and Microbiology

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