Overlapping, additive and counterregulatory effects of type II and i interferons on myeloid dendritic cell functions
TheScientificWorldJournal, ISSN: 1537-744X, Vol: 11, Page: 2071-2090
2011
- 7Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef7
- Captures24
- Readers24
- 24
Article Description
Dendritic cells (DCs) are central player in immunity by bridging the innate and adaptive arms of the immune system (IS). Interferons (IFNs) are one of the most important factors that regulate both innate and adaptive immunity too. Thus, the understanding of how type II and I IFNs modulate the immune-regulatory properties of DCs is a central issue in immunology. In this paper, we will address this point in the light of the most recent literature, also highlighting the controversial data reported in the field. According to the wide literature available, type II as well as type I IFNs appear, at the same time, to collaborate, to induce additive effects or overlapping functions, as well as to counterregulate each one's effects on DC biology and, in general, the immune response. The knowledge of these effects has important therapeutic implications in the treatment of infectious/autoimmune diseases and cancer and indicates strategies for using IFNs as vaccine adjuvants and in DC-based immune therapeutic approaches. Copyright © 2011 Loredana Frasca and Roberto Lande.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81455139878&origin=inward; http://dx.doi.org/10.1100/2011/873895; http://www.ncbi.nlm.nih.gov/pubmed/22125457; http://www.hindawi.com/journals/tswj/2011/873895/; https://dx.doi.org/10.1100/2011/873895; https://www.hindawi.com/journals/tswj/2011/873895/
Hindawi Limited
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