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Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

bioRxiv, ISSN: 2692-8205
2020
  • 32
    Citations
  • 0
    Usage
  • 0
    Captures
  • 6
    Mentions
  • 264
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    32
  • Mentions
    6
    • News Mentions
      6
      • News
        6
  • Social Media
    264
    • Shares, Likes & Comments
      264
      • Facebook
        264

Most Recent News

Sorry, a Coronavirus Infection Might Not Be Enough to Protect You

Immune cells can learn the vagaries of a particular infectious disease in two main ways. The first is bona fide infection, and it’s a lot like being schooled in a war zone, where any lesson in protection might come at a terrible cost. Vaccines, by contrast, safely introduce immune cells to only the harmless mimic of a microbe, the immunological equivalent of training guards to recognize invaders b

Article Description

Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. One Sentence Summary: Broad immune perturbations in severe COVID-19

Bibliographic Details

Kuri-Cervantes, Leticia; Pampena, M Betina; Meng, Wenzhao; Rosenfeld, Aaron M; Ittner, Caroline A G; Weisman, Ariel R; Agyekum, Roseline; Mathew, Divij; Baxter, Amy E; Vella, Laura; Kuthuru, Oliva; Apostolidis, Sokratis; Bershaw, Luanne; Dougherty, Jeannete; Greenplate, Allison R; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Gouma, Sigrid; Weirick, Madison E; Arevalo, Claudia P; Bolton, Marcus J; Goodwin, Eileen C; Anderson, Elizabeth M; Hensley, Scott E; Jones, Tiffanie K; Mangalmurti, Nilam S; Luning Prak, Eline T; Wherry, E John; Meyer, Nuala J; Betts, Michael R

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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