BDNF induces its own release to mediate presynaptic plasticity
bioRxiv, ISSN: 2692-8205
2021
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BDNF induces its own release to mediate presynaptic plasticity (Updated May 22, 2023)
2023 JUN 06 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- According to news reporting based on a preprint
Article Description
The brain-derived neurotrophic factor (BDNF) and its effector Tropomyosin receptor kinase B (TrkB) mediate diverse forms of activity-dependent synaptic plasticity implicated in learning, neural circuit refinement, and brain diseases, including epilepsy and mood disorders. Here, we report that activity-dependent release of presynaptic BDNF elicits the release of postsynaptic BDNF in a TrkB- and calcium-dependent manner. This BDNF-induced BDNF release was required for the induction of presynaptic long-term potentiation (LTP) of excitatory transmission in the mouse dentate gyrus. Tonic and phasic activity of presynaptic type-1 cannabinoid receptors suppressed BDNF release and dampened LTP, while exposure to enriched environment elicited BDNF-mediated LTP. In addition to mediating presynaptic plasticity, BDNF-induced BDNF release could be an important mechanism in synaptic stabilization during the maturation and refinement of neuronal connections.
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