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Sensory target detection at local and global timescales reveals a hierarchy of supramodal dynamics in the human cortex

bioRxiv, ISSN: 2692-8205
2022
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Article Description

To ensure survival in a dynamic environment, the human neocortex monitors input streams forwarded from different sensory organs for important sensory events. Which principles govern whether different senses share common or modality-specific networks for sensory target detection? We examined whether complex targets evoke sustained supramodal activity while simple targets rely on modality-specific networks with short-lived supramodal contributions. In a series of hierarchical multisensory target detection studies (n=77, of either sex) using Electroencephalography, we applied a temporal cross-decoding approach to dissociate supramodal and modality-specific cortical dynamics elicited by rule-based global and feature-based local sensory deviations within and between the visual, somatosensory and auditory modality. Our data show that each sense implements a cortical hierarchy which orchestrates supramodal target detection responses operating on local and global timescales at successive processing stages. Across different sensory modalities, simple feature-based sensory deviations presented in temporal vicinity to a monotonous input stream triggered an MMN-like local negativity which decayed quickly and early whereas complex rule-based targets tracked across time evoked a P3b-like global ERP response which generalised across a late time window. Converging results from temporal cross-modality decoding analyses across different datasets, we reveal that global ERP responses are sustained in a supramodal higher-order network whereas local ERP responses canonically thought to rely on modality-specific regions evolve into short-lived supramodal activity. Taken together, our findings demonstrate that cortical organisation largely follows a gradient in which short-lived modality-specific as well as supramodal processes dominate local responses whereas higher-order processes encode temporally extended abstract supramodal information fed forward from modality-specific cortices.

Bibliographic Details

Maria Niedernhuber; Tristan A. Bekinschtein; Federico Raimondo; Jacobo D. Sitt

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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