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Proliferation drives quorum sensing of microbial products in human macrophage populations

bioRxiv, ISSN: 2692-8205
2022
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  • Mentions
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    • News Mentions
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Most Recent News

Proliferation drives quorum sensing of microbial products in human macrophage populations (Updated January 30, 2023)

2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- According to news reporting based on a preprint

Article Description

Macrophages coordinate the initial host inflammatory response to tissue infection, as well as mediating the reparative phase, by producing growth factors that promote tissue repair. One model of this functional dichotomy is that peripherally recruited monocyte-derived macrophages drive acute inflammatory responses to infection, whereas tissue-resident macrophages are responsible for tissue repair. Alternatively, inflammation and repair may be inter-dependent molecular programs, such that both recruited and resident cells have equivalent capacity to contribute. Repeated exposure to pathogenic challenge results in innate tolerance, which may also alter the contributions of discrete macrophage populations to inflammation or repair. In this study a village model of tissue resident and recruited macrophages was created using induced pluripotent stem cell-derived macrophages and peripheral blood monocyte-derived macrophages, respectively. Population responses to repeated exposure to lipopolysaccharide were assessed with single-cell RNA sequencing and donors demultiplexed with Vireo. A subset of genes escaped classical tolerance programs in the iPSC, but not monocyte-derived macrophages, and this was associated with differences in their proliferative capacity. This suggests that targeting the proliferative resident macrophages would be most effective to limit inflammatory signaling.

Bibliographic Details

Nadia Rajab; Yair D.J. Prawer; Paul W. Angel; Christine A. Wells; Linden J. Gearing; Ruqian Lyu; Davis J. McCarthy; Sean M. Grimmond; Andrew L. Laslett

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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