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A New Hope for Liquid Biopsies: Early Detection of Pancreatic Cancer By Means of Protease Activity Detection in Serum Applying a Hierarchical Decision Structure

medRxiv
2022
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A New Hope for Liquid Biopsies: Early Detection of Pancreatic Cancer By Means of Protease Activity Detection in Serum Applying a Hierarchical Decision Structure

2022 NOV 09 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- According to news reporting based on a preprint

Article Description

Over the last 6 years, five-year survival rate for pancreatic cancer patients has increased from 6 to 10% after the initial diagnosis, which makes it one of the deadliest cancer types. This disease is known as the “silent killer” because early detection is challenging due to the location of the pancreas in the body and the nonspecific clinical symptoms. The Bossmann group has developed ultrasensitive nanobiosensors for protease/arginase detection comprised of Fe/FeO nanoparticles, cyanine 5.5, and designer peptide sequences linked to TCPP. Initial data obtained from both gene expression analysis and protease/arginase activity detection in serum indicated the feasibility of early pancreatic cancer detection. Several matrix metalloproteinases (MMPs, -1, -3, and -9), cathepsins (CTS) B and E, neutrophil elastase, and urokinase plaminogen activator (uPA) have been identified as candidates for proximal biomarkers. In this study, we have confirmed our initial results from 2018 performing serum sample analysis assays using a larger group sample size (n=159), which included localized (n=33) and metastatic pancreatic cancer (n=50), pancreatitis (n=26), and an age-matched healthy control group (n=50). The data obtained from the eight nanobiosensors capable of ultrasensitive protease and arginase activity measurements were analyzed by means of an optimized information fusion-based hierarchical decision structure. This permits the modeling of early-stage detection of pancreatic cancer as a multi-class classification problem. The most striking result is that this methodology permits the detection of localized pancreatic cancers from serum analyses with 96% accuracy.

Bibliographic Details

Obdulia Covarrubias-Zambrano; Jose Covarrubias; Stefan H. Bossmann; Madumali Kalubowilage; Sumia Ehsan; Asanka S. Yapa; Deepesh Agarwal; Balasubramaniam Natarajan; Anup Kasi

Cold Spring Harbor Laboratory

Medicine

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