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Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues

bioRxiv, ISSN: 2692-8205
2023
  • 0
    Citations
  • 0
    Usage
  • 0
    Captures
  • 1
    Mentions
  • 16
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    16
    • Shares, Likes & Comments
      16
      • Facebook
        16

Most Recent News

Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues

2023 FEB 09 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- According to news reporting based on a preprint

Article Description

We present a spatial omics approach that merges and expands the capabilities of independently performed in situ assays on a single tissue section. Our spatial multimodal analysis combines histology, mass spectrometry imaging, and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular weight metabolites across tissue regions. We demonstrate the potential of our method using murine and human brain samples in the context of dopamine and Parkinson's disease.

Bibliographic Details

Marco Vicari; Reza Mirzazadeh; Ludvig Larsson; Julia Foyer; Markus Ekvall; Paulo Czarnewski; Joakim Lundeberg; Anna Nilsson; Reza Shariatgorji; Patrik Bjärterot; Per E. Andrén; Hower Lee; Mats Nilsson; Xiaoqun Zhang; Per Svenningsson

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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