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Genetic profiling of Plasmodium ovale wallikeri relapses with microsatellite markers and whole-genome sequencing

bioRxiv, ISSN: 2692-8205
2023
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Most Recent News

Genetic profiling of Plasmodium ovale wallikeri relapses with microsatellite markers and whole-genome sequencing (Updated May 7, 2023)

2023 MAY 24 (NewsRx) -- By a News Reporter-Staff News Editor at Zika & Mosquito Daily -- According to news reporting based on a preprint

Article Description

Like Plasmodium vivax, both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitaemia originating from liver dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P. ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in Sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of eight highly polymorphic microsatellite markers, we genotyped 15 P. ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the four relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P. ovale spp.

Bibliographic Details

Valentin Joste; Émilie Guillochon; Jérôme Clain; Sandrine Houzé; Emma Colard-Itté; Frédéric Ariey; Romain Coppée

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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