A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson’s disease and dementia with Lewy bodies
medRxiv
2023
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- 1Mentions
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A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson's disease and dementia with Lewy bodies
2023 AUG 22 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health News Daily -- According to news reporting based on a preprint
Article Description
INTRODUCTION: Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) show heterogeneous brain atrophy patterns and common group-average analyses are limited in capturing individual differences. Neuroanatomical normative modelling overcomes this by comparing individuals to a large reference cohort. METHODS: We generated z-scores from T1w-MRI scans for each participant (108 PD; 61 DLB) relative to normative regional cortical thickness and subcortical volumes, modelled in a reference cohort (n=58,836). Outliers (z<-1.96) were aggregated across 169 brain regions per participant. We examined total outlier counts between high versus low visual performance in PD; and PD versus DLB; and tested associations between these and cognition. RESULTS: We found greater total outlier counts in PD poor visual performers, compared to high; and in DLB versus PD. Outlier counts were associated with global cognition in DLB, and visuoperception in PD. DISCUSSION: Neuroanatomical normative modelling shows promise as a clinically informative technique in PD and DLB.
Bibliographic Details
Cold Spring Harbor Laboratory
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