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A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson’s disease and dementia with Lewy bodies

medRxiv
2023
  • 1
    Citations
  • 0
    Usage
  • 0
    Captures
  • 1
    Mentions
  • 0
    Social Media
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  • Citations
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    • Citation Indexes
      1
      • CrossRef
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  • Mentions
    1
    • News Mentions
      1
      • News
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A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson's disease and dementia with Lewy bodies

2023 AUG 22 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health News Daily -- According to news reporting based on a preprint

Article Description

INTRODUCTION: Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) show heterogeneous brain atrophy patterns and common group-average analyses are limited in capturing individual differences. Neuroanatomical normative modelling overcomes this by comparing individuals to a large reference cohort. METHODS: We generated z-scores from T1w-MRI scans for each participant (108 PD; 61 DLB) relative to normative regional cortical thickness and subcortical volumes, modelled in a reference cohort (n=58,836). Outliers (z<-1.96) were aggregated across 169 brain regions per participant. We examined total outlier counts between high versus low visual performance in PD; and PD versus DLB; and tested associations between these and cognition. RESULTS: We found greater total outlier counts in PD poor visual performers, compared to high; and in DLB versus PD. Outlier counts were associated with global cognition in DLB, and visuoperception in PD. DISCUSSION: Neuroanatomical normative modelling shows promise as a clinically informative technique in PD and DLB.

Bibliographic Details

Rohan Bhome; S. Verdi; N. Hannaway; I. Dobreva; R. S. Weil; J. H. Cole; S. A. Martin; N. P. Oxtoby; G. Castro Leal; S. Rutherford; A. F. Marquand

Cold Spring Harbor Laboratory

Medicine

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