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Remotely controlled drug release in deep brain regions of non-human primates

bioRxiv, ISSN: 2692-8205
2023
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    Citations
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    Usage
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    Captures
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    Mentions
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    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
    • Citation Indexes
      1
      • CrossRef
        1
  • Mentions
    1
    • News Mentions
      1
      • 1

Most Recent News

Remotely controlled drug release in deep brain regionsof non-human primates (Updated March 28, 2024)

2024 APR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Daily News -- According to news reporting based on a preprint

Article Description

Many areas of science and medicine would benefit from selective release of drugs in specific regions of interest. Nanoparticle drug carriers activated by focused ultrasound—remotely applied, depth-penetrating energy—may provide such selective interventions. Here, we developed stable, ultrasound-responsive nanoparticles that can be used to release drugs effectively and safely in non-human primates. The nanoparticles were used to release propofol in deep brain visual regions. The release reversibly modulated the subjects’ visual choice behavior and was specific to the targeted region and to the released drug. Gadolinium-enhanced MRI imaging suggested an intact blood-brain barrier. Blood draws showed normal clinical chemistry and hematology. In summary, this study provides a safe and effective approach to release drugs on demand in selected deep brain regions at levels sufficient to modulate behavior.

Bibliographic Details

Wilson, Matthew G; Webb, Taylor D; Odéen, Henrik; Kubanek, Jan

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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