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Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis

medRxiv
2023
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Metric Options:   Counts1 Year3 Year

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  • Mentions
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    • News Mentions
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Post-COVID chronic neuropsychiatric symptoms persisting beyond one year from infection- a case-control study and network analysis

2023 NOV 07 (NewsRx) -- By a News Reporter-Staff News Editor at Vaccine Daily -- According to news reporting based on a preprint abstract, our

Article Description

Background Limited data about chronic post-COVID neuropsychiatric complaints exist in the literature. Aim: Our study aims to delineate the phenotypes of chronic neuropsychiatric symptoms among adult subjects recovering from their first COVID that occurred more than one year ago. We also aim to explore the clinical and socioeconomic risk factors of having a high loading of chronic neuropsychiatric symptoms. Methods We recruited a post-COVID group who suffered from their first pre-Omicron COVID more than a year ago, and a control group who had never had COVID. The subjects completed app-based questionnaires on demographic, socioeconomic and health status, a COVID symptoms checklist, mental and sleep health measures, and neurocognitive tests. Results The post-COVID group has a statistically significantly higher level of fatigue compared to the control group (p<0.001). Among the post-COVID group, the lack of any COVID vaccination before the first COVID and a higher level of material deprivation before the COVID pandemic predicts a higher load of chronic post-COVID neuropsychiatric symptoms. Partial correlation network analysis suggests that the chronic post-COVID neuropsychiatric symptoms can be clustered into two major (cognitive complaints -fatigue and anxiety-depression) and one minor (headache-dizziness) cluster. A higher level of material deprivation predicts a higher number of symptoms in both major clusters, but the lack of any COVID vaccination before the first COVID only predicts a higher number of symptoms in the cognitive complaints-fatigue cluster. Conclusions Our result suggests heterogeneity among chronic post-COVID neuropsychiatric symptoms, which are associated with the complex interplay of biological and socioeconomic factors.

Bibliographic Details

Steven Wai Ho Chau; Timothy Mitchell Chue; Rachel Ngan Yin Chan; Yee Lok Lai; Yaping Liu; Joey Wing Yan Chan; Yun Kwok Wing; Paul W.C. Wong; Shirley Xin Li; Paul Kay Sheung Chan; Christopher K.C. Lai; Thomas W.H. Leung

Cold Spring Harbor Laboratory

Medicine

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