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Advantages of Multi-shell Diffusion for Studies of Brain Development in Youth

bioRxiv, ISSN: 2692-8205
2019
  • 3
    Citations
  • 0
    Usage
  • 30
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    3
    • Citation Indexes
      3
      • CrossRef
        3
  • Captures
    30

Article Description

Diffusion tensor imaging (DTI) has advanced our understanding of how brain microstructure evolves over development. However, the proliferation of multi-shell diffusion imaging sequences has coincided with notable advances in the modeling of neuronal diffusion patterns, such as Neurite Orientation Dispersion and Density Imaging (NODDI) and Laplacian-regularized Mean Apparent Propagator MRI (MAPL). The relative utility of these newer diffusion models for understanding brain maturation remains sparsely investigated. Additionally, despite evidence that motion artifact is a major confound for studies of development, the relative vulnerability of these models to in-scanner motion has not been described. Accordingly, in a sample of 123 youth (ages 12-30) we evaluated DTI, NODDI, and MAPL for associations with age and in-scanner head motion at multiple scales, including mean white matter values, voxelwise analyses, and tractography-based structural brain networks. Our results reveal that multi-shell diffusion imaging sequences can be leveraged to robustly characterize neurodevelopment, even within the framework of DTI. However, these metrics of diffusion are variably impacted by motion, highlighting the importance of modeling choices for studies of movement-prone populations. Our findings suggest that while traditional DTI is sensitive to neurodevelopmental trends, contemporary modeling techniques confer key advantages for neurodevelopmental inquiries.

Bibliographic Details

Adam R. Pines; Matthew Cieslak; Graham L. Baum; Azeez Adebimpe; Diego G. Dávila; Robert Jirsaraie; Kristin Murtha; Desmond J. Oathes; Kayla Piiwaa; Adon F.G. Rosen; Sage Rush; Danielle S. Bassett; David R. Roalf; Theodore D. Satterthwaite; Philip A. Cook; Mark A. Elliott; Russell T. Shinohara

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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