The immune microenvironment and cancer metastasis
Cold Spring Harbor Perspectives in Medicine, ISSN: 2157-1422, Vol: 10, Issue: 4
2020
- 68Citations
- 62Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations68
- Citation Indexes68
- 68
- CrossRef45
- Captures62
- Readers62
- 62
Article Description
The dynamic interplay between neoplastic cells and the immune microenvironment regulates every step of the metastatic process. Immune cells contribute to invasion by secreting a cornucopia of inflammatory factors that promote epithelial-to-mesenchymal transition and remodeling of the stroma. Cancer cells then intravasate to the circulatory system assisted by macrophages and use several pathways to avoid recognition by cytotoxtic lymphocytes and phagocytes. Circulating tumor cells that manage to adhere to the vasculature and encounter premetastic niches are able to use the associated myeloid cells to extravasate into ectopic organs and establish a dormant microscopic colony. If successful at avoiding repetitive immune attack, dormant cells can subsequently grow into overt, clinically detectable meta-static lesions, which ultimately account to most cancer-related deaths. Understanding how disseminated tumor cells evade and corrupt the immune system during the final stages of metastasis will be pivotal in developing new therapeutic modalities that combat metastasis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85082978981&origin=inward; http://dx.doi.org/10.1101/cshperspect.a037424; http://www.ncbi.nlm.nih.gov/pubmed/31501262; http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/cshperspect.a037424; https://dx.doi.org/10.1101/cshperspect.a037424; https://perspectivesinmedicine.cshlp.org/content/10/4/a037424
Cold Spring Harbor Laboratory
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