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Interpreting spatial information and regulating mitosis in response to spindle orientation

Genes and Development, ISSN: 0890-9369, Vol: 23, Issue: 14, Page: 1613-1618
2009
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Review Description

The spindle position checkpoint (SPOC) is a regulatory mechanism that ensures accurate segregation of chromosomes in polarized cells during mitosis. In this issue of Genes & Development, Chan and Amon (pp. 1639-1649) identify a phosphoprotein phosphatase (Rts1-PP2A) as a new member of the checkpoint in budding yeast and define its role in interpreting spatial information during mitosis. © 2009 by Cold Spring Harbor Laboratory Press.

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